We used the OG drench when we had lots of chickens supplying eggs. We have been using Sarah Bristers Lamb Drench powder with equal results only because the OG drench is messy and needs refrigerated and we have fewer chickens. We have run out of the powder and made a batch of OG drench several times while waiting for shipping of the powdered. It literally is no difference other than convenience. I "assume" Egg Drench made simple is comparable to the powder we use, we just started on one brand before the other was on the market and have been pleased with it. I doubt anyone in this industry could tell the difference in a lamb fed OG drench vs powdered, however, I bet many in this industry can tell the difference in one fed with a drench vs one that wasn't. Especially at a long show. I think use whatever you feel best works for you. If you use the powder and run out, you can always use the OG drench. The benefit of the powder is convenience, easy to store and pack for shows, the benefit of the OG drench is even my small town of 289 people, the general store has what I need to make it so I am not in a jam if I forgot to order powdered or it was backordered.